Mouse PD-1 Antibody Pair Set
E-KAB-0310
| Size: | Price: | $499 | |
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Product Information
| Background | Programmed cell death 1 (PD-1,also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain,a stalk,a transmembrane domain,and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation,cytokine production,and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE . |
| Synonyms | CD279, PD1, PD-1, SLEB2 |
| Swissprot | Q02242 |
| Reactivity | Mouse |
| Usage | Detects Mouse PD-1 in ELISAs |
| Buffer | Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% pro |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
