Research Spotlight | JACS: A New Strategy for Osteoporosis Prevention and Clinical Treatment

The team of Professor Shunwu Fan, Ruikang Tang and Zhaoming Liu from Zhejiang University recently developed a smart “nano-sacrificial layer” (NaHCO3-TNLs) that can target bone surfaces and respond to external secreted acidification from osteoclasts, preventing osteoporosis. This study provided a novel understanding of osteoporosis therapy in biomedicine and clinical treatments.

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Fundamental Information

Title: Smart Nanosacrificial Layer on the Bone Surface Prevents Osteoporosis through Acid–Base Neutralization Regulated Biocascade Effects

Journal: JACS

IF：14.612(2019)

Institution of the first author:

Zhejiang University, China

Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, China

Institution of the corresponding author:

Zhejiang University, China

Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, China

Elabscience® Products Cited:

SUMMARY

Osteoporosis is a global chronic disease characterized by severe bone loss and high susceptibility to fragile fracture. It is widely accepted that the origin acidified microenvironment created by excessive osteoclasts causes irreversible bone mineral dissolution and organic degradation during osteoclastic resorption. However, current clinically available approaches are mainly developed from the perspective of osteoclast biology rather than the critical acidified niche.

Here, we developed a smart “nanosacrificial layer” consisting of sodium bicarbonate (NaHCO3)-containing and tetracycline-functionalized nanoliposomes (NaHCO3–TNLs) that can target bone surfaces and respond to external secreted acidification from osteoclasts, preventing osteoporosis.

In vitro and in vivo results prove that this nanosacrificial layer precisely inhibits the initial acidification of osteoclasts and initiates a chemically regulated biocascade to remodel the bone microenvironment and realize bone protection: extracellular acid–base neutralization first inhibits osteoclast function and also promotes its apoptosis, in which the apoptosis-derived extracellular vesicles containing RANK (receptor activator of nuclear factor-κ B) further consume RANKL (RANK ligand) in serum, achieving comprehensive osteoclast inhibition.

Our therapeutic strategy for osteoporosis is based on original and precise acid–base neutralization, aiming to reestablish bone homeostasis by using a smart nanosacrificial layer that is able to induce chemically regulated biocascade effects. This study also provides a novel understanding of osteoporosis therapy in biomedicine and clinical treatments.

Highlights

1. A smart “nanosacrificial layer” consisting of sodium bicarbonate (NaHCO3)-containing and tetracycline-functionalized nanoliposomes (NaHCO3–TNLs) was developed successfully in this research.

2. The developed NaHCO3–TNLs can target bone surfaces and respond to external secreted acidification from osteoclasts, preventing osteoporosis.

3. This study also provides a novel understanding of osteoporosis therapy in biomedicine and clinical treatments.

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