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ACE2 Polyclonal Antibody

Cat.No.:E-AB-12224

Host: Rabbit

Reactivity: H,M,R

Applications: IHC,ELISA

Summary of Verified Samples

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Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ACE2 Polyclonal Antibody at dilution 1:200.

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ACE2 Polyclonal Antibody at dilution 1:200.

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Test Application

Verified Samples

Reactivity Application
Human IHC
(esophagus cancer,lung cancer,)

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ACE2 Polyclonal Antibody at dilution 1:200.

Immunohistochemistry of paraffin-embedded Human lung cancer tissue using ACE2 Polyclonal Antibody at dilution 1:200.

Dilution

IHC 1:100-1:300

Related Reagents

Application Products
WB Western Blot Detection Kit(E-IR-R304)
IHC 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)(E-IR-R217)

Product Details

Clonality Polyclonal
Isotype IgG
Concentration 0.5 mg/mL
Storage Store at -20℃. Avoid freeze / thaw cycles.
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer, Cell Biology, Cardiovascular
Conjugation Unconjugated
Cellular cellular_localization Secreted and Cell membrane.
Tissue specificity Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

Immunogen Details

Immunogen Synthetic peptide of human ACE2
Abbre ACE2
Synonyms ACE 2,ACE related carboxypeptidase,ACE-related carboxypeptidase,ACE2,ACE2,ACEH,Angiotensin converting enzyme 2,Angiotensin converting enzyme homolog,Angiotensin converting enzyme like protein,Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2,Angiotensin I converting enzyme 2,Angiotensin-converting enzyme homolog,DKFZP434A014,EC 3.4.17,metalloprotease MPROT 15,Metalloprotease MPROT15,OTTHUMP00000022963,Processed angiotensin-converting enzyme 2
Swissprot Q9BYF1
Gene Accession NP_068576

Background

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
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