Cathepsin B Polyclonal Antibody
Summary of Verified Samples
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IHC
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using Cathepsin B Polyclonal Antibody at dilution 1:35.
Immunohistochemistry of paraffin-embedded Human liver using Cathepsin B Polyclonal Antibody at dilution of 1:100(Elabscience Product Detected by Lifespan).
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Datasheet
Test Application
Verified Samples
| Reactivity | Application |
| Human | IHC (lung cancer,liver,)   Immunohistochemistry of paraffin-embedded Human lung cancer tissue using Cathepsin B Polyclonal Antibody at dilution 1:35. Immunohistochemistry of paraffin-embedded Human liver using Cathepsin B Polyclonal Antibody at dilution of 1:100(Elabscience Product Detected by Lifespan). |
Dilution
IHC 1:50-1:100
Related Reagents
| Application | Products |
| WB | Western Blot Detection Kit(E-IR-R304) |
| IHC | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)(E-IR-R217) |
Product Details
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 0.3 mg/mL |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Cellular cellular_localization | Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Immunogen Details
| Immunogen | Recombinant protein of human CTSB |
| Abbre | CTSB |
| Synonyms | Amyloid precursor protein secretase,APP secretase,APPS,CATB,Cathepsin B heavy chain,Cathepsin B1,CathepsinB,CPSB,CTSB,cysteine protease,OTTHUMP00000116009,OTTHUMP00000229510,OTTHUMP00000229511,OTTHUMP00000229512,OTTHUMP00000229514,OTTHUMP00000229515,OTTHUMP00000229516,Preprocathepsin B |
| Swissprot | P07858 |
| Gene Accession | BC010240 |
Background
| The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. |
Citations(1)