Human sRANKL Antibody Pair Set
E-KAB-0246
| Size: | Price: | $499 | |
| Qty: |
-
+
|
Lead Time: Order now, ship in 3 days
Product Information
| Background | Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells,chief among which is induction of long lasting oscillations in the intracellular concentration of Ca 2+ resulting in the activation of NFATC1,which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation,in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation. |
| Synonyms | TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNLG6B, tumor necrosis factor superfamily member 11, TNF superfamily member 11 |
| Swissprot | O14788(140~317aa) |
| Reactivity | Human |
| Usage | Detects Human sRANKL in ELISAs |
| Buffer | Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% pro |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
