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TMPRSS2 Polyclonal Antibody

Cat.No.:E-AB-61783

Host: Rabbit

Reactivity: H

Applications: WB,IHC

Summary of Verified Samples

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Western blot analysis of extracts of 22Rv1 cells using TMPRSS2 Polyclonal Antibody at dilution of 1:2000.

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Price:   $129
Lead Time:   7~10 days
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Test Application

Verified Samples

Reactivity Application
Human WB
(22Rv1,)

Western blot analysis of extracts of 22Rv1 cells using TMPRSS2 Polyclonal Antibody at dilution of 1:2000.

IHC
(stomach cancer,)

Immunohistochemistry of paraffin-embedded Human stomach cancer using TMPRSS2 Polyclonal Antibody at dilution of 1:200 (40x lens).

Dilution

WB 1:500-1:2000 IHC 1:50-1:200

Related Reagents

Application Products
WB Western Blot Detection Kit(E-IR-R304)
IHC 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)(E-IR-R217)

Product Details

Isotype IgG
Concentration 1mg/mL
Storage Store at -20°C. Avoid freeze / thaw cycles.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Affinity purification
Research Areas Cancer, Cell Biology, Neuroscience
Conjugation Unconjugated
Cellular cellular_localization Cell membrane and Secreted. Activated by cleavage and secreted.
Tissue specificity Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.

Immunogen Details

Immunogen Recombinant fusion protein of human TMPRSS2 (NP_001128571.1).
Abbre TMPRSS2
Synonyms TMPRSS2,PP9284,PRSS10
Swissprot O15393
Gene ID 7113
Calculated MW 53kDa/57kDa
Observed MW 52kDa

Background

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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