Monoamine Oxidases (MAO) activity assay: obtain a amount of effective data in a short time

The function and significance of MAO

Monoamine oxidases (MAO) are a class of enzymes that catalyze the oxidative deamination of a variety of monoamine compounds, which are key to maintaining the homeostasis of monoamine neurotransmitters in the central nervous system. Abnormal expression of MAO disrupts the dynamic balance of monoamines in the central nervous system, leading to a variety of neurological diseases (such as schizophrenia, Alzheimer's disease, depression). Therefore, it is of great significance to measure MAO activity for the diagnosis of disease and drug development.

The topic application of MAO activity determination

Elabscience®-4-Dimethylaminobenzylamine

The patented method assists MAO activity detection

At present, the conventional assay methods (Kynuramine method and benzylamine method) in the market have disadvantages of long operation time and low sensitivity, which are not suitable for large quantities of detection.

Elabscience® have developed efficient and patent protection method for measurement of MAO activity:

4-Dimethylaminobenzylamine method. This method has higher sensitivity, better accuracy and shorter operation time. It greatly improves the efficiency of scientific research experiments, and meets the researchers' needs to obtain large quantities of effective data in a short time.

1. High sensitivity and small sample volume

Absolute OD of rat liver tissue assay by kits from different companies

2 Short reaction time:  only about 30 minutes

Reaction times of kits from different companies

3. High accuracy: the enzymatic reaction was linear within 60 min

Product generation - time curve

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